| Rank | State(s) | Date | Time | Dead | Injured | F-Scale | Town(s) |
|---|---|---|---|---|---|---|---|
| 1 | MO-IL-IN | March 18, 1925 | 1:01PM | 695 | 2027 | F5 | Murphysboro,Gorham, DeSoto |
| 2 | LA-MS | May 7, 1840 | 1:45 PM | 317 | 109 | F? | Nachez |
| 3 | MO-IL | May 27, 1896 | 6:30PM | 255 | 1000 | F4 | St. Louis, East St. Louis |
| 4 | MS | April 5, 1936 | 8:55 PM | 216 | 700 | F5 | Tupelo |
| 5 | GA | April 6, 1936 | 8:27 AM | 203 | 1600 | F4 | Gainesville |
| 6 | TX-OK-KS | April 9, 1947 | 6:05 PM | 181 | 970 | F5 | Glazier, Higgins, Woodward |
| 7 | LA-MS | April 24, 1908 | 11:45AM | 143 | 770 | F4 | Amite, Pine, Purvis |
| 8 | WI | June 12, 1899 | 5:40PM | 117 | 200 | F5 | New Richmond |
| 9 | MI | June 8, 1953 | 8:30 PM | 115 | 844 | F5 | Flint |
| 10 | TX | May 11, 1953 | 4:10PM | 114 | 597 | F5 | Waco |